Advanced Joint Support with Hyaluronic Acid for Dogs

Ingredient Benefits:

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Boswellia

An herb whose active ingredients are said to work as an anti-inflammatory by improving the blood supply to the affected area and enhancing the repair of local blood vessels damaged by inflammation. Boswellia may also be an inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation.

Chondroitin

Chondroitin is a component of connective tissues that are found in joint cartilage and bone. Chondroitin is believed to block enzymes that break down cartilage. Research has shown that when that when Chondroitin is combined with Glucosamine, cartilage breakdown is inhibited and new cartilage production is stimulated. This important substance is also a “building block” of the larger Hyaluronic Acid molecule.

Curcumin (Turmeric)

Curcumin is a naturally occurring compound that is found in the Indian spice turmeric and has been used for centuries for medicinal purposes. Recent evidence reinforces that curcumin has anti-inflammatory properties that inhibit the enzymes COX-2 and LOX, both of which appear to cause inflammation. Curcumin prevents connective tissue break down through inhibiting these destructive enzymes and, unlike conventional non steroidal anti-inflammatory drugs (NSAIDs), curcumin does not cause gastrointestinal side effects or ulcers. Patented for its unique composition ratio and use, we use Curcumin C3 Complex® in our products, which is comprised of three main chemical compounds – Curcumin, Demethoxycurcumin & Bisdemethoxycurcumin – collectively known as Curcuminoids. “Curcumin C3 complex® ” is a registered trademark of Sabinsa Corporation manufacturers of high quality ingredients.

Glucosamine HCl

An amino sugar that has been shown in studies to inhibit symptoms of advance joint problems. Glucosamine plays a key role in reducing inflammation and the enzymes that lead to inflammation that ultimately destroy cartilage. Glucosamine is naturally produced by the body, yet over time, the natural production of Glucosamine is inadequate to protect the joints from wear and tear and must be supplemented.

Hyaluronic Acid (HYALURONAN)

Hyaluronic Acid belongs to a class of molecules called glycosaminoglycans or GAGs. Because GAGs are highly polar, they attract water and bind with it creating natural shock absorption and lubrication of joints. Known also as Sodium Hyaluronate, Hyaluronan or “HA”, Hyaluronic Acid is a gel-like substance naturally found in the connective tissue space and the synovial fluid of movable joints. Orally administered HA has been shown in several studies to be bio-available (absorbable) and effective in replacing the damaged HA in the joint that is commonly caused by trauma, overuse, or every day wear and tear. Research studies have shown that using Hyaluronic Acid for dogs can be effective in supporting healthy joint function and mobility.

Licorice Root Extract

Licorice root, or glycyrrhiza glabra, is a concentrated herb that is frequently used as a medicinal remedy, as it contains antibacterial, antimicrobial and anti-inflammatory properties. A recent study published in “Phytomedicine” confirmed that licorice root exhibits its anti-inflammatory behavior through inhibiting prostaglandins and leukotrienes, which are lipid compounds that can cause inflammation. Licorice root may also have the ability to fight off certain infections due to its antibacterial and antimicrobial agents.

MSM

MSM (Methylsulfonylmethane) is a source of organic sulfur that plays many key roles in the body including the formation of proteins, enzymes and connective tissue. Sulfur is a naturally occurring mineral that is available in two forms: dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM). MSM occurs naturally in several species of plants, and is important in joint health and also helps form connective tissue — cartilage, tendons, and ligaments. It may also slow the nerve impulses that transmit pain signals, reducing discomfort.

Calcium Ascorbate – Vitamin C (Buffered)

Vitamin C from Calcium Ascorbate is an antioxidant that protects the body against damage from free radicals that accelerate the aging process and are largely responsible for many degenerative diseases. Vitamin C aids in the production of collagen, the protein necessary for the formation and repair of capillaries and connective tissues such as cartilage, skin, bone, tendons and ligaments. Calcium Ascorbate is added to many dog joint supplements to aid in the uptake of other ingredients.

Yucca

Yucca is a highly popular herb in folk medicine and widely believed to relieve pain and inflammation.The plant contains several physiologically active phytochemicals. It is a rich source of steroidal saponins which have diverse biological effects, including anti-protozoal activity. It has been postulated that saponins may have anti-inflammatory properties due to the suppression of intestinal protozoa which may have a role in joint inflammation. Yucca is also a rich source of polyphenolics, such as resveratrol, which is a natural phytoalexin that has proven antioxidant properties and is a free-radical scavenger.

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• Related Research Articles:
• [1] Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs.
  J Agric Food Chem 2008 Nov;56(22):10582-93 Lajos Balogh, Andras Polyak, Domokos Mathe, Reka Kiraly, Juliana Thuroczy, Marian Terez, Gyozo Janoki, Yaoting Ting, Luke R Bucci, Alexander G Schauss
• ” Reichling J, Schmokel H, Fitzi J, Bucher S, Saller R. Dietary support with Boswellia resin in canine inflammatory joint and spinal disease. Schweiz Arch Tierheilkd. 2004 Feb;146(2):71-9.
• “Siddiqui, M. Z. “Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview.” Indian Journal of Pharmaceutical Sciences 73.3 (2011): 255–261. PMC. Web. 24 May 2015.
• “Phytomedicine”; Dual Inhibitory Effect of Glycyrrhiza Glabra, C.V. Chandrasekaran, et al.; February 2011
• Linus Pauling Institute, Oregon State University; Curcumin; Jane Higdon, Ph.D., et al.; January 2009
• University of Maryland: Turmeric-Curcumin
• Kimmatkar N, Thawani N, et al. at MS Orthopaedics, Indira Gandhi Medical College, Nagpur, India, Phytomedicine 2003
• “Arthritis Research and Therapy”; A Double Blind, Randomized, Placebo Controlled Study of the Efficacy and Safety of ….; K. Sengupta, et al.; 2008
• Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis Cartilage. 2006 Mar;14(3):286-94
• Studies of synovial hyaluronic acid synthesis in canines: J Rheumatol. 1987 Dec;14(6):1150-5
• Anti-inflammatory and anti-arthritic effects of yucca schidigera:J Inflamm (Lond). 2006; 3: 6
• Miller MJS, Mehta K, Kunte S, Raut V, Gala J, Dhumale R, Shukla A, Tupalli H, Parikh H, Bobrowski P, Chaudhary J. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: A randomized controlled trial [ISRCTN38432711] J Inflammation. 2005;2:11. doi: 10.1186/1476-9255-2-11.

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